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We have a long standing philosophy of utilizing the most recent high quality studies available to guide our practice. We do not entertain studies that have a financial or organizational bias. We try to keep our information recent by utilizing research that has been performed within the last 10 years, however, with our stringent no bias policy, sometimes older studies remain relevant. As we value transparency, here is our working list of research that guide our principles.
Al-Safi, Z. A., Liu, H., Carlson, N. E., Chosich, J., Harris, M., Bradford, A. P., ... & Polotsky, A. J. (2016). Omega-3 fatty acid supplementation lowers serum FSH in normal weight but not obese women. The Journal of Clinical Endocrinology, 101(1), 324-333.
Bastos Maia, Sabina et al. “Vitamin A and Pregnancy: A Narrative Review.” Nutrients vol. 11,3 681. 22 Mar. 2019, doi:10.3390/nu11030681 Bawa, R., & Tyagi, S. (2017). Correlation of microelements like plasma copper and zinc concentrations with female infertility. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 6(6), 2351-2353.
Bensdorp, A. J., Tjon-Kon-Fat, R. I., Bossuyt, P. M. M., Koks, C. A. M., Oosterhuis, G. J. E., Hoek, A., ... & Van Golde, R. (2015). Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation. Bmj, 350, g7771.
Bordewijk, E. M., Nahuis, M., Costello, M. F., Van der Veen, F., Tso, L. O., Mol, B. W. J., & van Wely, M. (2017). Metformin during ovulation induction with gonadotrophins followed by timed intercourse or intrauterine insemination for subfertility associated with polycystic ovary syndrome. The Cochrane Library.
Chakravorty, R., Athwal, A., Sur, D., & Saha, R. (2016). A prospective, randomized trial comparing the effects of letrozole versus clomiphene citrate for induction of ovulation and pregnancy rate in women with polycystic ovary syndrome. Fertility Science and Research, 3(2), 93.
Chandyo RK, Ulak M, Kvestad I, Shrestha M, Ranjitkar S, Basnet S, Hysing M, Shrestha L, Strand TA. The effects of vitamin B12 supplementation in pregnancy and postpartum on growth and neurodevelopment in early childhood: Study Protocol for a Randomized Placebo Controlled Trial. BMJ Open. 2017 Aug 29;7(8):e016434. doi: 10.1136/bmjopen-2017-016434. PMID: 28851784; PMCID: PMC5634456.
Cyprian F, Lefkou E, Varoudi K, Girardi G. Immunomodulatory Effects of Vitamin D in Pregnancy and Beyond. Front Immunol. 2019 Nov 22;10:2739. doi: 10.3389/fimmu.2019.02739. PMID: 31824513; PMCID: PMC6883724.
Czeizel, A. E., Dudás, I., & Vereczkey, A. (2015). A Review of the Pivotal Studies Supporting the Use of Periconceptional Multivitamins in the Prevention of Congenital Abnormalities. Nutrition, Fertility, and Human Reproductive Function, 89.
Czeizel, A. E., Métneki, J., & Dudás, I. (1996). The effect of preconceptional multivitamin supplementation on fertility. International journal for vitamin and nutrition research, 66(1), 55-58. Dean, C. (2014). The magnesium miracle. Ballantine Books.
Diamond, M. P., Legro, R. S., Coutifaris, C., Alvero, R., Robinson, R. D., Casson, P., ... & Baker, V. (2015). Letrozole, gonadotropin, or clomiphene for unexplained infertility. New England Journal of Medicine, 373(13), 1230-1240.
Ding, Z., & Lian, F. (2015). Traditional Chinese medical herbs staged therapy in infertile women with endometriosis: a clinical study. International journal of clinical and experimental medicine, 8(8), 14085.
Dugoua, J. J., Seely, D., Perri, D., Koren, G., & Mills, E. (2008). Safety and efficacy of chastetree (Vitex agnus-castus) during pregnancy and lactation. Can J Clin Pharmacol, 15(1), e74-e79.
Fontana, R., & Torre, S. D. (2016). The deep correlation between energy metabolism and reproduction: a view on the effects of nutrition for women fertility. Nutrients, 8(2), 87.
Forbes S. Pregnancy sickness and parent-offspring conflict over thyroid function. J Theor Biol. 2014 Aug 21;355:61-7. doi: 10.1016/j.jtbi.2014.03.041. Epub 2014 Apr 8. PMID: 24721478.
Gangestad, S. W., Haselton, M. G., Welling, L. L., Gildersleeve, K., Pillsworth, E. G., Burriss, R. P., ... & Puts, D. A. (2016). How valid are assessments of conception probability in ovulatory cycle research? Evaluations, recommendations, and theoretical implications. Evolution and Human Behavior, 37(2), 85-96.
Gardner, D. K., & Simón, C. (Eds.). (2017). Handbook of in vitro fertilization. CRC press.
Genuis, R. A., & Genuis, S. J. (2017). Preconception care: the next frontier for improving maternal-child health care. Public health, 149, 57-59.
Gupta, S., Ghulmiyyah, J., Sharma, R., Halabi, J., & Agarwal, A. (2014). Power of proteomics in linking oxidative stress and female infertility. BioMed research international, 2014.
Harding KB, Peña-Rosas JP, Webster AC, Yap CM, Payne BA, Ota E, De-Regil LM. Iodine supplementation for women during the preconception, pregnancy and postpartum period. Cochrane Database Syst Rev. 2017 Mar 5;3(3):CD011761. doi: 10.1002/14651858.CD011761.pub2. PMID: 28260263; PMCID: PMC6464647.
Hart, R. J. (2016). Physiological aspects of female fertility: role of the environment, modern lifestyle, and genetics. Physiological reviews, 96(3), 873-909.
Hogg, S., & Vyas, S. (2018). Endometriosis update. Obstetrics, Gynaecology & Reproductive Medicine. Hosseini, B., & Eslamian, G. (2015). Association of micronutrient intakes with female infertility: review of recent evidence. Thrita, 4(1).
Ikenaga, H., Tanaka, Y., Shiotani, M., Rogoff, D., Shimizu, S., & Ishihara, O. (2017). Phase III trial comparing the efficacy and safety of recombinant‐or urine‐derived human chorionic gonadotropin for ovulation triggering in Japanese women diagnosed with anovulation or oligo‐ovulation and undergoing ovulation induction with follitropin‐alfa. Reproductive medicine and biology, 16(1), 45-51.
Jamison, J. (2003). Clinical Guide to Nutrition & Dietary Supplements in Disease Management. Churchill Livingstone. Kashani, L., & Akhondzadeh, S. (2017). Female Infertility and Herbal Medicine. 61, 3-7.
Khani, B., Mardanian, F., & Fesharaki, S. J. (2017). Omega-3 supplementation effects on polycystic ovary syndrome symptoms and metabolic syndrome. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences, 22.
Kessler, C., Stapelfeldt, E., Michalsen, A., Kowalcek, I., Kronpaß, L., & Dhruva, A. (2015). The effect of a complex multi-modality ayurvedic treatment in a case of unknown female infertility. Complementary Medicine Research, 22(4), 251-258.
Kloss, J. D., Perlis, M. L., Zamzow, J. A., Culnan, E. J., & Gracia, C. R. (2015). Sleep, sleep disturbance, and fertility in women. Sleep medicine reviews, 22, 78-87.
Liew SC, Gupta ED. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases. Eur J Med Genet. 2015 Jan;58(1):1-10. doi: 10.1016/j.ejmg.2014.10.004. Epub 2014 Nov 4. PMID: 25449138.
Liu, J., Chian, R. C., Ma, X., Wang, W., & Cui, Y. (2016). The pregnancy outcomes comparison on natural or controlled ovarian stimulation cycles in intrauterine insemination treatment: an analysis of 8,893 cycles. La Prensa Medica, 2016.
MacLean, C. H., Mojica, W. A., Morton, S. C., Pencharz, J., Garland, R. H., Tu, W., ... & Rhodes, S. (2004). Effects of Omega‐3 Fatty Acids on Lipids and Glycemic Control in Type II Diabetes and the Metabolic Syndrome and on Inflammatory Bowel Disease, Rheumatoid Arthritis, Renal Disease, Systemic Lupus Erythematosus, and Osteoporosis: Summary.
McEwen, H. J. L., Inglis, M. A., Quennell, J. H., Grattan, D. R., & Anderson, G. M. (2016). Deletion of Suppressor of Cytokine Signaling 3 from Forebrain Neurons Delays Infertility and Onset of Hypothalamic Leptin Resistance in Response to a High Caloric Diet. The Journal of Neuroscience, 36(27), 7142–7153.
McNulty H, Ward M, Hoey L, Hughes CF, Pentieva K. Addressing optimal folate and related B-vitamin status through the lifecycle: health impacts and challenges. Proc Nutr Soc. 2019 Aug;78(3):449-462. doi: 10.1017/S0029665119000661. Epub 2019 Jun 3. PMID: 31155015.
Means RT. Iron Deficiency and Iron Deficiency Anemia: Implications and Impact in Pregnancy, Fetal Development, and Early Childhood Parameters. Nutrients. 2020 Feb 11;12(2):447. doi: 10.3390/nu12020447. PMID: 32053933; PMCID: PMC7071168.
Najafipour, F., Rahimi, A. O., Mobaseri, M., Agamohamadzadeh, N., Nikoo, A., & Aliasgharzadeh, A. (2014). Therapeutic effects of stinging nettle (Urtica dioica) in women with Hyperandrogenism. Int J Current Res Acad Rev, 2(7), 153-160.
Nasimi Doost Azgomi, R., Zomorrodi, A., Nazemyieh, H., Fazljou, S. M. B., Sadeghi Bazargani, H., Nejatbakhsh, F., ... & Ahmadi AsrBadr, Y. (2018). Effects of Withania somnifera on Reproductive System: A Systematic Review of the Available Evidence. BioMed Research International, 2018.
Padayatty, S J, and M Levine. “Vitamin C: the known and the unknown and Goldilocks.” Oral diseases vol. 22,6 (2016): 463-93. doi:10.1111/odi.12446
Palacios, Cristina et al. “Vitamin D supplementation for women during pregnancy.” The Cochrane database of systematic reviews vol. 7,7 CD008873. 26 Jul. 2019, doi:10.1002/14651858.CD008873.pub4
Prasad, S., Tiwari, M., Pandey, A. N., Shrivastav, T. G., & Chaube, S. K. (2016). Impact of stress on oocyte quality and reproductive outcome. Journal of biomedical science, 23(1), 36.
Rajeswari, G., Gopal, P. S., Veerabhadrudu, B., & Suresh, E. (2016). Study of magnesium levels in polycystic ovarian syndrome. IJAR, 2(3), 610-613.
Roney, J. R., & Simmons, Z. L. (2015). Elevated psychological stress predicts reduced estradiol concentrations in young women. Adaptive Human Behavior and Physiology, 1(1), 30-40.
Rupa, K., Jain, K., Dutta, D., Gupta, S. M., & Chopra, K. (2018). Comparison of clinical outcomes in clomiphene citrate resistant infertile polycystic ovarian syndrome women after treatment with laparoscopic ovarian drilling (LOD) versus gonadotropins. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 7(2), 576-581.
Rumbold, Alice et al. “Vitamin E supplementation in pregnancy.” The Cochrane database of systematic reviewsvol. 2015,9 CD004069. 7 Sep. 2015, doi:10.1002/14651858.CD004069.pub3
Sharifzadeh F, Kashanian M, Koohpayehzadeh J, Rezaian F, Sheikhansari N, Eshraghi N. A comparison between the effects of ginger, pyridoxine (vitamin B6) and placebo for the treatment of the first trimester nausea and vomiting of pregnancy (NVP). J Matern Fetal Neonatal Med. 2018 Oct;31(19):2509-2514. doi: 10.1080/14767058.2017.1344965. Epub 2017 Jul 7. PMID: 28629250.
Sim, K. A., Partridge, S. R., & Sainsbury, A. (2014). Does weight loss in overweight or obese women improve fertility treatment outcomes? A systematic review. obesity reviews, 15(10), 839-850.
Singh, N., Bhalla, M., de Jager, P., & Gilca, M. (2011). An Overview on Ashwagandha: A Rasayana (Rejuvenator) of Ayurveda. African Journal of Traditional, Complementary, and Alternative Medicines, 8(5 Suppl), 208–213.
Singh S, Sandhu S. Thyroid Disease And Pregnancy. 2021 Jul 25. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 30860720.
Stoll, A. L. (2001). The omega-3 connection. The groundbreaking omega-3 antidepression diet and brain program. Simon & Schusster. NY, 303.
Summa, K. C., Vitaterna, M. H., & Turek, F. W. (2012). Environmental perturbation of the circadian clock disrupts pregnancy in the mouse. PLoS One, 7(5), e37668.
Tenório MB, Ferreira RC, Moura FA, Bueno NB, de Oliveira ACM, Goulart MOF. Cross-Talk between Oxidative Stress and Inflammation in Preeclampsia. Oxid Med Cell Longev. 2019 Nov 4;2019:8238727. doi: 10.1155/2019/8238727. PMID: 31781353; PMCID: PMC6875353.
Touzet, S., Rabilloud, M., Boehringer, H., Barranco, E., & Ecochard, R. (2002). Relationship between sleep and secretion of gonadotropin and ovarian hormones in women with normal cycles. Fertility and sterility, 77(4), 738-744.
Wagner, Carol L et al. “Health characteristics and outcomes of two randomized vitamin D supplementation trials during pregnancy: a combined analysis.” The Journal of steroid biochemistry and molecular biology vol. 136 (2013): 313-20. doi:10.1016/j.jsbmb.2013.01.002
Wang, J. X., Davies, M. J., & Norman, R. J. (2002). Obesity increases the risk of spontaneous abortion during infertility treatment. Obesity, 10(6), 551-554.
Wilson, R. D., Désilets, V., Wyatt, P., Langlois, S., Gagnon, A., Allen, V., ... & Koren, G. (2007). Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. Journal of obstetrics and gynaecology Canada, 29(12), 1003-1013.
Wuttke, W., Jarry, H., Christoffel, V., Spengler, B., & Seidlova-Wuttke, D. (2003). Chaste tree (Vitex agnus-castus)–pharmacology and clinical indications. Phytomedicine, 10(4), 348-357.
Zare, S., Nabiuni, M., Tayanloo, A., Hoseini, S., & Karimzadeh-Bardei, L. (2015). The effects of Urtica dioica extract on lipid profile, insulin resistance index and liver histology in polycystic ovary syndrome-induced Wistar rats. Advanced Herbal Medicine, 1(2), 23-33.
Zhong, Naer, and Jingnan Wang. “The efficacy of omega-3 fatty acid for gestational diabetes: a meta-analysis of randomized controlled trials.” Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology vol. 35,1 (2019): 4-9. doi:10.1080/09513590.2018.1480716
Zhu, J. L., Basso, O., Obel, C., Bille, C., & Olsen, J. (2006). Infertility, infertility treatment, and congenital malformations: Danish national birth cohort. Bmj, 333(7570), 679.
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